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Charles Sturt University
Charles Sturt University

Photo of  Mike Cahill Mike Cahill

BSc (Hons 1) in Zoology & Biochemistry, School of Biological Sciences, Faculty of Science, UNSW, Sydney, 1988.
Ph.D. in Molecular Cell Biology, School of Pathology, Faculty of Medicine, University of New South Wales, Sydney. 1996.

Dr Cahill completed a BSc (hons I) in Zoology and Biochemistry from the School of Biological Sciences at the University of NSW, Sydney, and subsequently obtained his PhD in Molecular Cell Biology (on proto-oncogene c-fos gene regulation and signal transduction) as an external student of the Department of Pathology, School of Medicine of the University of NSW. The laboratory work for his doctoral degree was performed in the group of Prof. Alfred Nordheim, who was then at the Institute of Molecular Biology at the Medizinische Hochschule Hannover, in Germany. After doing his PhD and follow-up postdoc work in Hannover he spent one year as a postdoctoral Scientist working on Fos-family gene regulation at The John Curtin School of Medical Research at the Australian National University in Canberra, where he was introduced through a guest lecture by Professor Keith Williams to the then emerging field of Proteomics. Working in the field of signal transduction, he was then trying to identify kinases that anonymously phosphorylated my target proteins, only to frustratingly vanish unidentified back into the cloaking shadows of the unchartered cytoplasm from whence they had appeared. This field of proteomics offered new strategies to tackle the biology cell signalling, and indeed the broad panorama of cell biology.

These were exciting developments, and he decided immediately that he wanted to work in proteomics because it showed the potential to eventually address just the questions that he was trying to ask in his own research. At that stage (in 1996) the Australian Proteome Analysis Facility (APAF) had just been established, and he assessed that there was no chance of him securing funds in Australia to work on proteomics. Therefore he moved back to Germany where his Ex-PhD supervisor, Alfred Nordheim, had just accepted a Professorship at the Department of Molecular Biology, in the Interfaculty Institute of Cell Biology at the University of Tuebingen, and he offered Dr Cahill the opportunity to initiate proteomics activities in his brand new and empty institute. Those activities were the direct genetic ancestor of the modern Proteomics Centre at Tuebingen, which was founded in 2003.

However before that centre was officially opened he had left academia. Realising that proteomics techniques detected only a fraction of all cellular proteins, he was working on strategies to improve protein detection: involving a vision of large two-dimensional protein separation gels combined with sensitive multiplexed radioactive protein detection. This led to his co-foundation of a proteomics-based biotechnology company in February 2000. One year later that company underwent a corporate merger to form ProteoSys AG, based in Mainz Germany, where he initially served on the managerial board and as Chief Research Officer and co-founding scientist until he left to return to Australia in 2007. At ProteoSys, with the support of a talented team of colleagues, they were able to develop the technological proteomics platform envisioned in the business plan and to experimentally focus those newly acquired tools onto several cancer systems. Those methods in turn revealed exciting cell biology, which closed the circle on his professional interests of oncogenic signal transduction.

In 2008 Dr Cahill 'moved back home' by re-entering academic life in Australia as a biochemistry lecturer at Charles Sturt University in Wagga Wagga, where the climate and landscape are similar to Wellington NSW, where he grew up. And here he is.

In June 2010 the People's Daily newspaper, the most influential in China, featured his work in an article on international collaborative research at Charles Sturt University. (Original article in Chinese; Google translation into English). See his publications in collaboration with Chinese colleagues.

On 11 July 2014 Dr Cahill featured in a Prime7 News TV item about cancer research at Charles Sturt University in Wagga.

Paradise Rediscovered

In 2012 the Daily Advertiser (Wagga) published an article about his book Paradise Rediscovered: "Lecturer's search for longer life" (9th July, 2012).

If you are interested in Paradise Rediscovered (2012, Glass House Books, Brisbane), and how it relates to modern medical sciences, see Dr Cahill's Research page. To learn more about the book visit http://ipoz.biz/Titles/PR.htm or read about developments subsequent ti publication on https://www.facebook.com/ParadiseRediscovered.

Since August 2013 Dr Cahill has been a scientific advisor for Cognition Therapeutics Inc (Pittsburgh; www.cogrx.com),* whose small molecule pharmaceuticals that target PGRMC1 reverse symptoms of Alzheimer's Disease in mice, such as reducing plaque density and improving memory functions. Read more about PGRMC1 research under the Research and Publication headings. Because cancer and Alzheimer's disease are extremely relevant to the ageing communities of CSU's geographical footprint, Dr Cahill's molecular cell research aligns excellently with CSU's strategic research aims to benefit its communities.

* For legal reasons: Any advice provided to Cognition Therapeutics by Dr Cahill is explicitly his own opinion, and does not represent the views of Charles Sturt University or its management.

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Teaching

Teaching philosophy

Dr Cahill teaches using a blended learning approach where students have access to multiple media and avenues to achieve their learning objectives. These range from face to face lectures, podcasting, linking to online e-resources, lab practicals, problem based learning modules, and one-on-one mentoring, as well as answering student queries by email, telephone, BLOG thread, or chat. My door is always open to students, but they are advised to make an appointment if they want to be certain that I am available.

Current subjects taught
  • BCM210 Foundations & Techniques in Biochemistry (Lecturer).
  • BCM211 Foundations in Biochemistry (Lecturer).
  • BMS241 Molecular Cell Biology (Lecturer).
  • BMS243 Nutrition, Metabolism & Human Disease (Subject Coordinator & Lecturer).
  • BMS301 Medical Science Special Topic. (Intense 1:1 student supervision).
  • BMS346 Genomics Proteomics and Bioinformatics (Subject Coordinator & Lecturer).

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Research

Research Interests
  • Signal transduction
  • Proteomics technologies and their application
  • Cancer research
  • The role of PGRMC1 in cancer signalling and cellular metabolic regulation
  • Human ageing
Research Profiles
The role of PGRMC1 in cancer and metabolic regulation

At ProteoSys AG, a proteomics-centred company which I co-founded, I headed cancer research. After that indication area was discontinued due to insufficient funds I could choose any result in the then current cancer portfolio to pursue in an academic career. By far the most promising protein in the cancer portfolio of ProteoSys, the veritable jewel in the crown, was the protein Progesterone Receptor Membrane Component 1 (PGRMC1), which we had detected to be differentially phosphorylated between breast cancers differing in expression levels of the estrogen receptor. Whereas these results had been submitted for patent applications between 2004-2007 (WO2006029836; WO2007039189; WO2008037449), a chronic internal funding shortage for the project within the company had prevented the level of biological characterisation that will be necessary to elucidate the precise role of PGRMC1 in cancer. That elucidation represents my current research priority. Although it is a small protein, PGRMC1 has been implicated in a wide variety of biological functions (See Cahill 2007). In fact it is highly likely that PGRMC1 is involved at a crucial nexus position in a convergent inter-regulated yet hitherto undescribed signalling system (which includes the regulation of steroid synthesis) whose activity determines the survival prognosis of cancer cells (Neubauer et al., 2008). PGRMC1 also regulates the steroid-mediated onset of vasculogenesis that is so crucially important in metastatic biology (Neubauer et al., 2009), and is induced at the time and place in cancers where it regulate the onset of oxygen-independent tumour-specific energy metabolism (Figure 1)

Figure 1. The induction of PGRMC1 (red) in the hypoxic zone (redox stress) surrounding the necrotic core (central dark green staining) of a ductal carcinoma in situ from a breast cancer patient tissue section. The estrogen receptor (outer green staining) stains in a halo surrounding the hypoxic zone but is downregulated where PGRMC1 is upregulated; From Neubauer et al., (2008). In the same paper we showed that PGRMC1 phosphorylation differed between breast cancers, and that phosphorylation site mutants protected cancer cells from redox induced death.

The induction of PGRMC1

Since August 2013 I have been a scientific advisor for for Cognition Therapeutics Inc (Pittsburgh; www.cogrx.com),* who have developed anti-Alzheimer drugs which target PGRMC1 leading to reversal of the symptoms of Alzheimer's Disease in mice. This work was published in November 2014 by Izzo et al. (http://dx.doi.org/10.1371/journal.pone.0111899).

Projects available on PGRMC1

There are several potential research projects available to study the role of this exciting protein in cancer and cell metabolism. Methods involve cell imaging, cloning, mutagenesis, cell culture, and general cell molecular biological techniques. Students interested in pursuing Honours or Doctoral studies in a stimulating scientific environment working on the mechanistic molecular cell biology of cancer or pharmacology are encouraged to contact me. The commitment to either undergraduate or postgraduate study is a vitally important step that hones the future career path of any student. The PGRMC1 signalling project offers a scientific environment and a compellingly urgent research topic that will enable students who are willing to apply themselves to reach their scientific potential at this crucial stage of their careers. The School of Biomedical Sciences is also a great place to work, and we have a lot of fun here too!

Human Ageing

The earliest stories passed down to us in myths and sagas contain reference to secret and powerful treatments that could prolong the ageing process in those that took them, or to extremely long lived gods or royal characters. These include the Indo-European gods (e.g., the apples of the Hesperides and Ambrosia in Greek, the apples of Idun and Mead for the Germanic Aesir, Homa and Soma for the early Indo-Iranians), Manetho's long lived early predynastic Egyptian kings, the Epic of Gilgamesh (the earliest attested literature, where the survivor of Noah's flood had the secret of immortality), and the related flood account in Genesis, where Noah's immediate male ancestors all lived many hundreds of years, including Methuselah, the oldest of them all ("But what good is livin', when no girl will give-in to a man who is 900 years"). Clearly, this theme has long aroused the excitement of many story tellers.

Since the late 1990's I have been interested in ancient myths and stories concerning long-lived individuals from bygone days. In my book - Paradise Rediscovered (2012, Glass House Books, Brisbane). I argue that many of these old tales contain some historically accurate information that permits us to attempt reconstruction of a social system that existed perhaps more than 8000 years ago. This includes the location of a religious centre that was flooded by rising sea levels at the mouth of the modern Black Sea after a monumental clash of two cultures, as described by Plato's Critias and Timaeus, The Book of Enoch, and the Epic of Gilgamesh, and indeed in residual form is reflected in biblical Genesis. You can see my poster on this topic (TEXTUAL SUPPORT FOR A 6400 BC BLACK SEA FLOOD) as presented at the ATLANTIS 2011 conference (25-27 June 2011, Santorini, Greece). Two chapters by me in the conference proceedings discuss the hypothesis. Most of those ancient tales also contain as a recurrent element of precisely the same theme of human longevity referred to above, which caused me to wonder whether some elite section of humanity (i.e. 'the gods') in preantiquity might have commanded a real elixir to extend lifespan, as reconstructed from those same reliable sources, whose recipe has long since been lost and which lingers only as legend in our collective consciousness. Paradise Rediscovered explores that hypothesis.

Recent findings in cell and organism biology have made this idea particularly piquant. Over the past two decades ageing studies in model organisms have revealed evolutionarily conserved pathways that affect the rate of ageing in organisms from yeast, roundworms, and fruit flies to mice (Guarente & Kenyon, 2000; Kenyon, 2010; Kenyon 2011), leading to speculation that ageing may be a treatable phenomenon in the future (Hadley et al., 2005). One such pathway involves the mTOR (mammalian Target Of Rapamycin) signalling pathway. Experimental developments in model organisms over the last 20 years have led to the recent demonstration that inhibiting mTOR in mice with the dug rapamycin indeed increases the life-span of those mice (Harrison et al., 2009). Although the effect was relatively modest, and the ages of the longest lived mice in the rapamycin treatment were no longer than the controls, this represented a veritable landmark result. Rapamycin is an immune immunosuppressant that destroyed the immune systems of those mice, but the result demonstrated preliminary proof of concept and proof of mechanism that ageing might be pharmacologically addressed in mammals (and hence in humans). These are the two major acceptance criteria for the pharmaceutical industry to accept a project into their high throughput screening pipelines. It is quite feasible (but don't hold your breath) that in the foreseeable future humans may age more slowly, so that a 60 year old (or 180 year old) person may retain the body of a modern 25 year old by growing old more slowly. The advent of antibiotics after WWII heralded a medical revolution of similar importance, and such a breakthrough in ageing research is quite within the realms of possibility in the coming years. Using results from comparative mythology, comparative ethnography, and archaeology, it may just be possible reconstitute the ingredients of a putative ancient elixir, as described in - Paradise Rediscovered. This represents an ongoing research interest of mine.

Read the Wagga Daily Advertiser article "Lecturer's search for longer life" about Paradise Rediscovered (published 9th July, 2012).

Learn more about Paradise Rediscovered at http://ipoz.biz/Titles/PR.htm, and https://www.facebook.com/ParadiseRediscovered.

* For legal reasons: Any advice provided to Cognition Therapeutics by Dr Cahill is explicitly his own opinion, and does not represent the views of Charles Sturt University or its management.

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Peer-reviewed Publications
  •  Izzo NJ, Xu J, Zeng C, Kirk MJ, Mozzoni K, Silky C, Rehak C, Yurko R, Look G, Rishton G, Safferstein H, Cruchaga C, Goate A, Cahill MA, Arancio O, Mach RH, Craven R, Head E, LeVine H (III), Spires-Jones TL, Catalano SM. 2014. Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers II: Sigma-2/PGRMC1 Receptors Mediate Abeta 42 Oligomer Binding and Synaptotoxicity. PloSOne. 9:e111899. http://dx.doi.org/10.1371/journal.pone.0111899
  • Drozdowicz-Tomsia K, Anwer AG, Cahill MA, Madlum KN, Maki AM, Baker ME, Goldys EM. 2014. Multiphoton FLIM imaging reveals free to bound NADH ratio changes associated with metabolic inhibition. J Biomedical Optics. 19:86016. http://www.ncbi.nlm.nih.gov/pubmed/25140884  
  • Zhou J, Yu Q, Chen R, Seeger H, Fehm T, Cahill MA, Mueck AO, Neubauer H. 2013. Medroxyprogesterone acetate-driven increase in breast cancer risk might be mediated via cross-talk with growth factors in the presence of progesterone receptor membrane component-1. Maturitas. 76:129-33. http://www.ncbi.nlm.nih.gov/pubmed/23856385
  • Neubauer H, Ruan X, Schneck H, Seeger H, Cahill MA, Liang Y, Mafuvadze B, Hyder SM, Fehm T, Mueck AO. 2013. Overexpression of progesterone receptor membrane component 1: possible mechanism for increased breast cancer risk with norethisterone in hormone therapy. Menopause. 20:504-10. http://www.ncbi.nlm.nih.gov/pubmed/23615641
  •  Neubauer H, Ruan X, Schneck H, Seeger H, Cahill MA, Liang Y, Mafuvadze B, Hyder SM, Fehm T, Mueck AO. 2013. Overexpression of progesterone receptor membrane component 1: possible mechanism for increased breast cancer risk with norethisterone in hormone therapy. Menopause. 20(5):504-10. http://www.ncbi.nlm.nih.gov/pubmed/23856385
  • Schneck H, Ruan X, Seeger H, Cahill MA, Fehm T, Mueck AO, Neubauer H. 2013. Membrane-receptor initiated proliferative effects of dienogest in human breast cancer cells. Gynecol Endocrinol. 29:160-3. http://www.ncbi.nlm.nih.gov/pubmed/23116217
  • Ruan X, Schneck H, Schultz S, Fehm T, Cahill MA, Seeger H, Chen R, Yu Q, Mueck AO, Neubauer H. 2012. Nomegestrol acetate sequentially or continuously combined to estradiol did not negatively affect membrane-receptor associated progestogenic effects in human breast cancer cells. Gynecol Endocrinol. 28:863-6. http://www.ncbi.nlm.nih.gov/pubmed/22494101 
  • Ruan X, Neubauer H, Yang Y, Schneck H, Schultz S, Fehm T, Cahill MA, Seeger H, Mueck AO. 2012. Progestogens and membrane-initiated effects on the proliferation of human breast cancer cells. Climacteric. 15:467-72  http://www.ncbi.nlm.nih.gov/pubmed/22335423
  • Neubauer H, Chen R, Schneck H, Knorrp T, Templin MF, Fehm T, Cahill MA, Seeger H, Mueck AO. 2011. New insight on a possible mechanism of progestogens in terms of breast cancer risk. Horm Mol Biol Clin Invest. 6:185-92. http://dx.doi.org/10.1515/HMBCI.2010.082
  • Neubauer H, Yang Y, Seeger H, Fehm T, Cahill MA, Tong X, Alfred O Mueck AO. 2011. The presence of a membrane-bound progesterone receptor sensitizes the estradiol-induced effect on the proliferation of human breast cancer cells. Menopause. 18:845-50Published online26/4/2011. http://www.ncbi.nlm.nih.gov/pubmed/21532513
  • Bryant KJ, Bidgood MJ, Lei P-W, Taberner M, Salom C, Kumar V, Lee L, Church WB, Courtenay B, Smart BP, Gelb MH, Cahill MA, Graham GG, McNeil HP, Scott KF. 2011. A bifunctional role for Group IIa secreted phospholipase A2 in human rheumatoid fibroblast-like synoviocyte arachidonic acid metabolism. J Biol Chem. 286:2492-503. http://www.ncbi.nlm.nih.gov/pubmed/21068383
  • Neubauer H, Adam G, Seeger H, Mueck AO, Solomayer E, Wallwiener D, Cahill MA, Fehm T. 2009. Membrane-Initiated effects of progesterone on proliferation and activation of VEGF in breast cancer cells. Climacteric. 12:230-9. http://www.ncbi.nlm.nih.gov/pubmed/19340614
  • Langer R, Ott K, Specht K, Becker K, Lordick F, Burian M, Herrmann K, Schrattenholz A, Cahill MA, Schwaiger M, Hofler H, Wester HJ. 2008. Protein expression profiling in esophageal adenocarcinoma patients indicates association of heat-shock protein 27 expression and chemotherapy response. Clin Cancer Res. 14:8279-87. http://www.ncbi.nlm.nih.gov/pubmed/19088045
  • Neubauer H, Clare S, Wozny W, Schwall GP, Poznanovic S, Stegmann W, Vogel U, Sotlar K, Wallwiener D, Kurek R, Fehm T, Cahill MA. 2008. Breast cancer proteomics reveals correlation between Estrogen Receptor status and differential phosphorylation of PGRMC1. Breast Cancer Research. 10:R85. http://www.ncbi.nlm.nih.gov/pubmed/18922159
  • Cahill MA. 2007. Progesterone Receptor Membrane Component 1: an integrative review. J Ster Biochem Mol Biol, 105:16-36. http://www.ncbi.nlm.nih.gov/pubmed/17583495
  • Cahill MA, Vogt JA, Servos J, Wozny W, Schwall GP, Groebe K, Schrattenholz A, Stegmann W. 2007. Metabolically stable isotope labeling prior to electrophoretic protein separation reveals differences in fractional synthesis rates between mitochondrial aldehyde dehydrogenase isoforms. J Chromatogr A, 1161:67-70. http://www.ncbi.nlm.nih.gov/pubmed/17466314
  • Wozny W, Schroer K, Schwall GP, Poznanovic S, Stegmann W, Dietz K, Rogatsch H, Schaefer G, Huebl H, Klocker H, Schrattenholz A, Cahill MA. 2007. Differential radioactive quantification of protein abundance ratios between benign and malignant prostate tissues: Cancer association of annexin A3. Proteomics, 7:313-322. http://www.ncbi.nlm.nih.gov/pubmed/17205602
  • Hunzinger C, Wozny W, Schwall GP, Poznanovic S, Stegmann W, Zengerling H, Schoepf R, Groebe K, Cahill MA, Osiewacz HD, Jägemann N, Bloch M, Dencher NA, Krause F, Schrattenholz A. 2006. Comparative Profiling of the Mammalian Mitochondrial Proteome: Multiple Aconitase-2 Isoforms including N-formylkynurenine modifications as part of a protein biomarker signature for reactive oxidative species. J Proteome Res, 5:625-33. http://www.ncbi.nlm.nih.gov/pubmed/16512678
  • Neubauer H, Clare SE, Kurek R, Fehm T, Wallwiener D, Sotlar K, Nordheim A, Wozny W, Schwall GP, Poznanovic S, Sastri C, Hunzinger C, Stegmann W, Schrattenholz A, Cahill MA. 2006. Breast cancer proteomics by laser capture microdissection, sample pooling, 54 cm immobilised pH gradient isoelectric focussing, and differential iodine radioisotope detection. Electrophoresis, 27:1840-52. http://www.ncbi.nlm.nih.gov/pubmed/16645950
  • Poznanovic P, Wozny W, Schwall GP, Sastri C, Hunzinger C, Stegmann W, Schrattenholz A, Buchner A, Gangnus R, Burgemeister R, Cahill MA. 2005. Differential radioactive proteomic analysis of microdissected renal cell carcinoma tissue by 54 cm isoelectric focusing in serial immobilized pH gradient gels. J Proteome Res, 4:2117-25. http://www.ncbi.nlm.nih.gov/pubmed/16335957
  • Poznanovic P, Schwall G, Zengerling H, Cahill MA. 2005. Isoelectric focusing in serial immobilized pH gradient gels to improve protein separation in proteomic analysis. Electrophoresis, 26:3185-3190. http://www.ncbi.nlm.nih.gov/pubmed/16041705
  • Vogt JA, Hunzinger C, Schroer K, Holzer K, Bauer A, Schrattenholz A, Cahill MA, Schillo S, Schwall G, Stegmann W, Albuszies G. 2005. Determination of fractional synthesis rates of mouse hepatic proteins via metabolic 13C-labeling, MALDI-TOF MS and analysis of relative isotopologue abundances using average masses. Anal Chem, 77:2034-42. http://www.ncbi.nlm.nih.gov/pubmed/15801735
  • Schrattenholz A, Wozny W, Klemm M, Schroer K, Stegmann W, Cahill MA. 2005. Differential and quantitative molecular analysis of ischemia complexity reduction by isotopic labeling of proteins using a neural embryonic stem cell model. J Neurol Sci, 229-230:261-7. http://www.ncbi.nlm.nih.gov/pubmed/15760649
  • Davezac N, Tondelier D, Lipecka J, Fanen P, Demaugre F, Debski J, Dadlez M, Schrattenholz A, Cahill MA, Edelman A. 2004. Global proteomic approach unmasks involvement of keratins 8 and 18 in the delivery of cystic fibrosis transmembrane conductance regulator (CFTR)/deltaF508-CFTR to the plasma membrane. Proteomics, 4:3833-44. http://www.ncbi.nlm.nih.gov/pubmed/15529338
  • Schrattenholz A, Klemm M, Cahill MA. 2004. Potential of comprehensive Toxico-Proteomics: Quantitative and Differential Mining of Functional Proteomes from Native Samples. ATLA (Alternatives To Laboratory Animals) 32(Supplement 1):123-131. http://www.cababstractsplus.org/google/abstract.asp?AcNo=20043109968
  • Kurek R, Neubauer H, Clare S, Sotlar K, Nordheim A, Cahill M, Poznanovic S, Berth M, Kolbe M, Wallwiener D. 2003. Identifikation differentiell exprimierter Proteine in unterschiedlichen Progressionsstufen von Mammakarzinomgewebe mittels Lasermikrodissektion und Proteomanalyse. Geburtsh Frauenheilk, 63:H-S 09. http://www.thieme-connect.com/ejournals/abstract/gebfra/doi/10.1055/s-2003-815167>
  • Vogt JA, Schroer K, Holzer K, Hunzinger C, Klemm M, Biefang-Arndt K, Schillo S, Cahill MA, Schrattenholz A, Matthies H, Stegmann W. 2003. Protein abundance quantification in embryonic stem cells using incomplete metabolic labelling with 15N amino acids, MALDI-TOFMS, and analysis of relative isotopologue abundances of peptides. Rapid Comm Mass Spectrom, 17:1273-1282. http://www.ncbi.nlm.nih.gov/pubmed/12811750
  • Cahill MA, Wozny W, Schwall G, Schroer K, Holzer K, Poznanovic S, Hunzinger C, Vogt JA, Stegmann W, Matthies H, Schrattenholz A. 2003. Analysis of relative isotopologue abundances for quantitative profiling of complex protein mixtures labelled with the acrylamide/D3-acrylamide alkylation tag system. Rapid Comm Mass Spectrom, 17:1283-1290. http://www.ncbi.nlm.nih.gov/pubmed/12811751
  • Poland J, Cahill MA*, Sinha P. 2003. Isoelectric focusing in long immobilized pH gradient gels to improve protein separation in proteomic analysis. Electrophoresis, 24:1271-1275. (*corresponding author)http://www.ncbi.nlm.nih.gov/pubmed/12707921
  • Vuong GL, Weiss, SM, Kammer W., Priemer M, Vingron M, Nordheim A, Cahill MA. 2000. Improved sensitivity proteomics by post-harvest alkylation and radioactive labelling of proteins. Electrophoresis, 21:2594-2605. http://www.ncbi.nlm.nih.gov/pubmed/10949135
  • Heidenreich O, Neininger A, Schratt G, Zinck R, Cahill MA, Engel K, Kotlyarov A, Kraft R, Kostka S, Gaestel M, Nordheim A. 1999. MAPKAP Kinase 2 phosphorylates Serum Response Factor in vitro and in vivo. J Biol Chem, 274:14434-14443. http://www.ncbi.nlm.nih.gov/pubmed/10318869
  • Cahill MA. 1997. c-Fos transrepression revisited. FEBS Lett, 400: 9-10. http://www.ncbi.nlm.nih.gov/pubmed/9000503>
  • Müller JM, Cahill MA, Rupec RA, Baeuerle PA, Nordheim A. 1997. Antioxidants as well as oxidants activate c-fos via Ras-dependent activation of extracellular-signal-regulated kinase 2 and Elk-1. Eur J Biochem, 244:45-52. http://www.ncbi.nlm.nih.gov/pubmed/9063444>
  • Cahill MA, Nordheim A, Xu YZ. 1996. Crosslinking of SRF to the c-fos SRE CArG box guanines using photo- active thioguanine oligodeoxynucleotides. Biochem Biophys Res Commun, 229:170-175. http://www.ncbi.nlm.nih.gov/pubmed/8954101
  • Cahill MA, Janknecht, R., and Nordheim, A. 1996. Signalling pathways: Jack of all cascades. Curr Biol, 6: 16-19. http://www.ncbi.nlm.nih.gov/pubmed/8805215
  • Cahill MA, Peter ME, Kischkel FC, Chinnaiyan AM. Dixit VM, Krammer PH, Nordheim A. 1996. CD95 (APO-1/Fas) induces activation of SAP kinases downstream of ICE-like proteases. Oncogene, 13:2087-96. http://www.ncbi.nlm.nih.gov/pubmed/8950975
  • Müller JM, Cahill MA, Nordheim A, Baeuerle PA. 1996. The transcription factor TCF/Elk-1: a nuclear sensor of changes in the cellular redox status. Adv Exp Med Biol, 387:77-84. http://www.ncbi.nlm.nih.gov/pubmed/8794197
  • Ernst, WH., Janknecht, R., Cahill, MA., and Nordheim, A. 1995. Transcriptional repression mediated by the serum response factor. FEBS Lett, 357:45-49. http://www.ncbi.nlm.nih.gov/pubmed/8001676
  • Zinck R*, Cahill MA*, Kracht M, Sachsenmaier C, Hipskind RA, Nordheim A. 1995. Protein synthesis inhibitors reveal differential regulation of mitogen- activated protein kinase and stress-activated protein kinase pathways that converge on Elk-1. Mol Cell Biol, 15:4930-4938. (*the first two authors contributed equally)http://www.ncbi.nlm.nih.gov/pubmed/7651411
  • Janknecht R, Cahill MA, Nordheim A. 1995. Signal integration at the c-fos promoter. Carcinogenesis, 16:443-450. http://www.ncbi.nlm.nih.gov/pubmed/7697796
  • Cahill MA, Ernst WH, Janknecht R, Nordheim A. 1994. Regulatory squelching. FEBS Lett, 344:105-108. http://www.ncbi.nlm.nih.gov/pubmed/8187867
  • Cahill MA, Nordheim A, Janknecht R. 1994. Co-occurrence of CArG boxes and TCF sites within viral genomes. Biochem Biophys Res Commun, 205:545-551. http://www.ncbi.nlm.nih.gov/pubmed/7999077
Books
  • Cahill, M.A. (2012). Paradise rediscovered: the roots of civilisation (Brisbane, Glass House Books.) Published as two paperback volumes or a single volume eBook. ISBN 9781921869488 (Vol 1, 556pp), ISBN 9781921869844 (Vol 2, PB, 543pp); ISBN 9781921869495 (Combined Volumes 1 and 2, ePub, pdf) http://ipoz.biz/Titles/PR.htm
Book Chapters
  • Wozny W, Schwall GP, Sastri CS, Poznanovic S, Stegmann W, Hunzinger C, Groebe K, Cahill MA. 2009. Differential ProteoTope radioactive quantification of protein abundance ratios. Chapter 42 in: Protein Protocols Handbook (3rd ed). JM Walker (Ed). Meth Mol Biol (Humana, NY). ISBN: 978-1-58829-880-5. pp. 449-477. http://www.cplbookshop.com/contents/C3584.htm
  • Poznanovic S, Wozny W, Zengerling H, Schwall GP, Cahill MA. 2009. 54 cm Serial Immobilized pH Gradient Isoelectric Focusing Over pH 4-9. Chapter 30 in: Protein Protocols Handbook (3rd ed). JM Walker (Ed). Meth Mol Biol (Humana, NY). ISBN: 978-1-58829-880-5. pp. 269-277. http://www.cplbookshop.com/contents/C3584.htm
  • Neubauer H, Fehm T, Schuetz C, Speer R, Solomayer E, Schrattenholz A, Cahill MA, Kurek R. 2007. Proteomic expression profiling of breast cancer. In: Recent Results in Cancer Research, 176:89-120 Targeted Therapies in Cancer. Dietel M (Ed). (Springer, Berlin) ISBN:3-540-46090-X. http://www.buchspektrum.de/bestellen.asp?isbn=354046090X
  • Cahill MA, Nordheim A. 2001. Proteome research in an academic environment. In: Proteomics: from protein sequence to function. Pennington SR & Dunn MJ (Eds). (New York: Bios Scientific Publishers Ltd.). ISBN: 9781859962961. pp. 277-288. http://beta.garlandscience.com/product/isbn/9781859962961
  • Cahill MA., Althöfer H, Nordheim A. 1996. MADS-domain transcription factors and their accessory proteins (TCFs): nuclear targets for growth control signals. In: Cancer Genes: Functional Aspects, Mihich E (Ed). (New York: Plenum Press), pp. 161-175. ISBN 978-0-306-45482-0. http://www.springer.com/medicine/oncology/book/978-0-306-45482-0
  • Cahill MA, Janknecht R, Nordheim A. 1995. Signal uptake by the c-fos serum response element. In: Inducible Gene Expression, Vol. 2. Baeuerle PA (Ed). (Boston: Birkhäuser Press), ISBN: 3764337346, pp. 39-73. http://www.springer.com/medicine/book/978-0-8176-3734-7
Patent Applications
Invited Presentations
  • Charles Sturt University, School of Biomedical Science Research Seminar Series. August 7th 2009. Towards the role(s) of the putative membrane steroid receptor PGRMC1 in breast cancer. M. Cahill.
  • John Curtin School of Medical Research School Seminar Series, Australian National University. 31st July, 2009. Towards the role(s) of the putative membrane steroid receptor PGRMC1 in breast cancer. M. Cahill.
  • St. Vincent's Hospital Cancer Seminar Series, Melbourne. July 21st 2009. Towards the role(s) of the putative membrane steroid receptor PGRMC1 in breast cancer. M. Cahill.
  • University of Newcastle, Cancer Research Unit Seminar, Newcastle NSW. 15th June 2009. Towards the role(s) of the putative membrane steroid receptor PGRMC1 in breast cancer. M. Cahill.
  • Ludwig Institute for Cancer Research, Royal Melbourne Hospital. 5th June 2009. Towards the role(s) of the putative membrane steroid receptor PGRMC1 in breast cancer. M. Cahill.
  • Monash Institute of Medical Research Seminar Series. Monash Centre for Cancer Research. 16th April 2009. Towards the role(s) of the putative membrane steroid receptor PGRMC1 in breast cancer. M. Cahill.
  • Proteomic Forum 2009, March 29 to April 2, Berlin. Advisory board. Cahill M.
  • 2nd BMBF Colloquium Proteomics: New efficient methods for functional proteome analysis. 30 May - 1 June 2005. Potsdam, Germany. ProteoTope analysis of cancer proteomes. Cahill M.
  • 1st Annual Meeting of the Portugese Proteomics Network - ProCura. 17 November 2003. Lisbon, Portugal. Molecular Analysis of Complex Biological Systems. Cahill M.
  • Computational Systems Biology (CSB) - Its future in Europe. Workshop organized by DG Research of the European Commission. 10-11 September 2003. Brussels. Embryonic stem cell differentiation: Possible elements of a coordination action. Cahill M.
  • 1st BMBF Proteomics-Statusseminar. 11.-12. May, 2003. Bad Honnef, Germany. ProteoTope analysis of microdissected proteomes. Schwall G, Wozny W, Poznanovic S, C Sastri C, Kurek R, Clare S, Schroer K, Stegmann W, Schrattenholz A, Cahill MA.
  • Forum Life Science 2003 together with the 21st DECHEMA Annual Biotechnology Meeting. 2-4 April 2003(3 April). Technical University of Munich, Garching, Germany. ProteoTope analysis of breast cancer genes. Cahill M, Wozny W, Sastri C, Kurek R, Clare S, Poznanovic S, Stegmann W, Schrattenholz A.
  • GBM Workshop "Bioanalytik fur junge Wissenschaftler", 6-8 November 2000, Rauischholzhausen (near Giessen) Germany. ProteoTope Proteomics. Cahill M.
  • Electrophoresis Forum 99, October 25-27, 1999, Technical University of Munich, Garching. Improved sensitivity proteomics by post-harvest alkylation and radioactive labelling of proteins. Cahill M.

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Grants

Academic Grants: M. Cahill at Charles Sturt University (commenced 07/2008)
Grant body Ref Status Applicants Title Period - value
Charles Sturt University Competitive Grants A105-900-639-40002 funded M. Cahill Structures of the protein pgrmc1 in complex with its ligands heme and progesterone 2009-2010 AU$ 15,000
Charles Sturt University Publication Assistance Scheme CSU A105-900-639-30007 funded M. Cahill Stable Isotope based Proteomics: An Approach for unbiased quantification and quality control 2009 AU$ 1,000
Charles Sturt University Grant-writing Assistance Scheme CSU A105-900-639-40003 funded M. Cahill Anti-ageing properties of plants (Grant writing assistance) 2009 AU$ 1,000
Grants to ProteoSys AG written and/or managed by M. Cahill

ProteoSys AG was also involved in the following grants, which I either co-planned or managed within the company:

Granting body Grant Title Reference Number Period Financial Sum approved
(To ProteoSys)
MY ROLE
European FP6

PRIORITY 1

(LifeSciHealth)
Development of new technologies for low abundance proteomics: Application to cystic fibrosis. (NEUPROCF) LSHG-CT-2005-512044 1.6.2005 - 31-5-2008 €300,000
I AUTHORED AND COSTED THE PROJECT APPLICATION FOR PROTEOSYS
European FP6

PRIORITY 1:

(LifeSciHealth)
Role of Mitochondria in Conserved Mechanisms of Ageing (MIMAGE) LSHM-CT-2004-512020 1.1.2005 - 31.12.2010 €571,405
I AUTHORED AND COSTED THE PROJECT APPLICATION FOR PROTEOSYS
European FP5

Quality of life management of living resources
Development of UltraSensitive methods for proteome: application to cystic fibrosisProposal Acronym : (EUROPROCF) European FP5 Proposal Nr. QLRT 2000-01335 1.9.2001 - 31.8.2004 €715,415-
I COAUTHORED AND COSTED THE PROJECT, & SUPERVISED THE PROJECT AT PROTEOSYS.
European FP5

Quality of life management of living resources
Prostate disorders: procurement of biomarkers & Pharmaceuticals (ProCure BioPharm) European FP5 Proposal Nr. QLRT-2000-00159 1.1.2001 - 31.12.2004  €214,291
I PLANNED & COAUTHORED THE PROTEOMICS PROJECT, & REPRESENTED PROTEOSYS AG WITHIN THE CONSORTIUM.
German Human Genome Project Proteomanalyse von Brustkrebsgenen.

Partners: Frauenklinik Tübingen, Decodon GmbH, Zellbiologie Tubingen
01 KW0102 1.9.2001 - 30.6.2005

 €554,595-

I COAUTHORED & PLANNED THE PROTEOMICS, & WAS CONSORTIUM COORDINATOR.
BMBF

Proteomics
Fraktionierung und Gewinnung von "Low Abundandance" Proteinen in der Proteomanalytik. 0312831 1.11.2001- 31.12.2003

 €678,304-

I CONCEIVED & AUTHORED THE PROJECT, & WAS CONSORTIUM COORDINATOR

I was consortium coordinator of these grants.

Academic Grants to M. Cahill at the University of Tübingen

(Joint proteomics applications with Prof. Alfred Nordheim)

Granting body Grant Title Reference Number Period Financial Sum approved
MY ROLE
Deutsche Forschungs Gesellschaft (DFG) Mass-Spectrometry Initiative. Medizinische Proteomanalyse: massenspektrometrische Identifizierung von Proteinen klinischer Biopsate. DFG 120/11-1

(A 227)
October 1999 DM 719,000
I COAUTHORED THE GRANT WITH PROF. NORDHEIM. -> PE Biosystems Q-STAR purchase.
University Clinics of Tübingen MALDI TOF Purchase. Tübingen Clinics internal August 1998 DM 400,000
I COAUTHORED THE GRANT WITH PROF. NORDHEIM.

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