School of Biomedical Sciences

Prof Lexin Wang is an academic cardiologist specializing cardiovascular pharmacology and cardiac electrophysiology. After completing his training in clinical cardiology at Peking Union Medical College in 1988, he worked as physician and academic at the Peking University, Royal Perth Hospital and the University of Tasmania School of Medicine, respectively. He jointed CSU in 1998 to initiate pharmacology and therapeutics programs, which now serve several courses in the Faculty of Science.

Prof Wang is the head of CSU Cardiovascular Research Group. He is an elected Fellow of the Cardiac Society of Australia and New Zealand. He also holds adjunct appointments in several Australian and Chinese universities, such as Honorary Professor and Director of the Department of Cardiology at Taishan Medical College. He is a recipient of the CSU Vice-Chancellor’s Award for Research Excellence in 2002 and 2006.

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Teaching

Current subjects taught

• PHM430 Therapeutics
• BMS 301 Medical Science Special Topics

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Research

Research interests are centered on the management of cardiac arrhythmia, heart failure, hypertension and coronary artery disease.

Current projects include:

1. Riverina Heart Failure Study;
2. T wave alternans in predicting  sudden cardiac death in patients with heart failure or acute coronary syndrome;
3. Prevalence and impact of depression in patients with chronic heart failure;
4. Electrophysiological disturbances in patients with hypertension;
5. Early diagnosis and catheter treatment of acute pulmonary embolism

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Publications

More than 220 peer-reviewed articles in prominent national and international journals. Some recent publications are listed as below:

• Li YB, Liang MT, Yang Y, Hou XH, Kong JB, Xu JL, Wang LX. Impact of acute pulmonary embolism on plasma and tissue hepatocyte growth factor: an experimental study. Experimental Lung Research  (in press)
• He SW, Wang LX. Impact of anaemia on the outcomes of chronic heart failure: a meta-analysis and systemic review. Congestive Heart Failure 2009; 15(3):123-130.
• Yao DK, Jia SQ, Wang LX, Li HW, Zhang YC, Wang YL. Therapeutic effect of urapidil on myocardial perfusion in patients with ST-elevation acute coronary syndrome. European Journal of Internal Medicine  2009; 20: 152-157.
• Wu TG, Zhao Q, Huang WG, Wei JR, Chen SW, Zhao J, Huang LP, Wang LX. Effect of intracoronary tirofiban in patients undergoing percutaneous coronary intervention for acute coronary syndrome.  Circulation Journal 2008; 72(10):1605-1609.
• Wu TG, Li WH, Lin ZQ, Wang LX.Effects of folic acid on cardiac myocyte apoptosis in rats with streptozocin-induced diabetes.  Cardiovascular Drugs and Therapy 2008; 22:299-304. 
• Kong XQ, Wang MZ, Wang LX, Kong JB, Qi XW, Chen SF. Effects of Xuezhikang on proliferation and adhesive capacity of cultured endothelial progenitor cells. Current Therapeutic Research 2008; 69(3):252-259. 
• Jelinek HF, Kolbe C, Wang LX, Oxbrow D. Identification of hypertension and efficacy of treatment in a rural Australian population.Clinical and Experimental Hypertension 2008; 30(5):359-366
• Wang LX, Curran S, Ball P, White F. Pharmacotherapy for atrial fibrillation in hospitalized older patients in Australia. Current Therapeutic Research 2008; 69(6):514-524.
• Zhang YZ, Xing XW, He B, Wang LX. Effects of testosterone on cytokines and left ventricular remodelling following heart failure. Cellular Physiology and Biochemistry 2007; 20:847-852.
• Sun TW, Wang LX, Zhang YZ. Prognostic Value of B-type natriuretic peptide in patients with chronic and advanced heart failure. Internal Medicine Journal 2007; 37 (3):168–171.
• Zhao Q, Wu TG, Jiang ZF, Chen GW, Lin Y, Wang LX. Effect of ß blockers on ß3-adrenoceptor expression in rats with chronic heart failure. Cardiovascular Drugs & Therapy 2007; 21:85-90.
• Kong DG, Kong XQ, Wang LX. Effect of cardiac lymph flow obstruction on cardiac collagen synthesis and interstitial fibrosis. Physiological Research 2006; 55(3): 253-258.
• Zeng CL, Wei TM, Jin L, Wang LX. Accuracy of B-type natriuretic peptide in diagnosing left ventricular dysfunction in dialysis-dependent patients. Internal Medicine Journal 2006; 36(9): 552-557.
• Wei TM, Zeng CL, Chen LP, Chen QY, Zhao RY, Lu GX, Lu CL, Wang LX. Bedside tests of B-type natriuretic peptide in the diagnosis of left ventricular diastolic dysfunction in hypertensive patients. European Journal of Heart Failure 2005; 7(1):75-79.
• Chen LP, Wei TM, Zeng CL, Chen QY, Shi ZH, Wang LX. Effect of radiofrequency catheter ablation on plasma B-type natriuretic peptide. Pacing and Clinical Electrophysiology 2005; 28(3):200-204.6.
• Wang LX, Yang HB, Zhang YZ. Recurrence of symptomatic atrial fibrillation after successful catheter ablation of atrioventricular accessory pathways: a multivariate regression analysis. International Journal of Clinical Practice 2005; 59(8):886-890.
• Li JF, Wang LX, Wang J. Video-assisted thoracoscopic sympathectomy for congenital long QT syndromes. Pacing and Clinical Electrophysiology 2003; 26 (4):870–873.
• Wang LX, Yang AC, Kilpatrick. Effect of procainamide on transmural ventricular repolarization. Cardiovascular Drugs and Therapy 2002; 16:335-339.
• Wang LX, Wu TG. Predictors of long-term success in catheter ablation of atrioventricular nodal reentrant tachycardia: a multivariate regression analysis. International Journal of Cardiology 2002; 86:289-294.
• Wang LX. QT dispersion from body surface ECG does not reflect the spatial dispersion of left ventricular repolarization in sheep. Pacing and Clinical Electrophysiology 2000; 23:359-364.

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