BMS243 Nutrition, Metabolism & Human Disease (8)

CSU Discipline Area: Biomedical Science (BIMSC)

Duration: One session

Abstract:

In this subject, students examine metabolism pertinent to the study of nutrition. The subject relies on a basic understanding of human metabolic pathways and extends students' understanding of the pathogenesis of various common diseases in biochemical detail.

+ Subject Availability Modes and Locations

Session 2
Internal	Wagga Wagga
Distance	Wagga Wagga

Continuing students should consult the SAL for current offering details: BMS243

Where differences exist between the Handbook and the SAL, the SAL should be taken as containing the correct subject offering details.

Assumed Knowledge:

BCM211 (or BMS205 or BCM210 ) and BMS240

It is assumed that students have either completed or are concurrently studying BMS208 Human Nutrition.

Objectives:

Upon successful completion of this subject, students should:

- be able to integrate metabolic knowledge from earlier biochemistry subjects to describe the metabolic adaptations (and their underlying regulation) to a range of physiological states;
- be able to appreciate the role of metabolic lesions on the pathogenesis of common human diseases;
- be able to describe the influence of dietary factors on the development of common diseases such as liver disease, diabetes mellitus and cardiovascular disease;
- be able to appreciate the influences of reactive oxygen species and antioxidants on the pathogenesis of common human diseases;
- be able to describe how the metabolic changes in nutritional diseases such as marasmus and kwashiorkor result in the observed clinical symptoms for these two diseases;
- be able to describe the underlying principles of inherited metabolic disorders, with special reference to phenylketonuria and galactosaemia; and
- be able to describe how metabolic changes in both physiological and pathological states may impact on human nutritional requirements

Syllabus:

The subject will cover the following topics:

- Revision of the metabolism of carbohydrates, lipids and amino acids;
- Metabolic adaptations to the post-prandial and starvation states - the role of hormones as metabolic regulators;
- Metabolic adaptations to severe exercise - the scientific basis of nutritional loading;
- Metabolic adaptations to stress, especially in severely ill people. Nutritional implications;
- Free radical biology
- Liver function (metabolism of alcohol, detoxification, nutrient reserves, bile production, excretion);
- Liver pathology (pathological effects of alcohol, jaundice, hepatitis, cirrhosis);
- Endocrine control of blood glucose levels, with special reference to the diabetes mellitus (its pathogenesis, diagnosis, control and monitoring);
- The pathogenesis of cardiovascular disease, with special reference to the dietary influences on risk factors;
- The metabolic syndrome - its development, diagnosis and use as a risk factor for cardiovascular disease and diabetes mellitus;
- Metabolic changes in severe nutritional deficiency diseases such as marasmus and kwashiorkor - nutritional implications;
- Metabolic changes in cancer cachexia - nutritional implications;
- Inherited metabolic disorders, with special reference to the metabolic lesions resulting in phenylketonuria and galactosaemia - their nutritional implications;

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