BMS302 Clinical Biochemistry 2 (8)
CSU Discipline Area: Biomedical Science (BIMSC)
Duration: One session
Abstract:
The subject covers clinical endocrinology, advanced immunochemical techniques, toxicology and drug monitoring. Clinical biochemistry methods of investigating endocrine disorders, drugs and genetic defects are considered.
+ Subject Availability Modes and Locations
| Session 1 | |
|---|---|
| Internal | Wagga Wagga |
| Distance * | Wagga Wagga |
*This subject offering contains a residential school. Please view following information for further details.
Continuing students should consult the SAL for current offering details: BMS302
Where differences exist between the Handbook and the SAL, the SAL should be taken as containing the correct subject offering details.
Prerequisite(s):
Objectives:
Upon successful completion of this subject, students should:
* be able to demonstrate the steps involved in setting up an immunoassay for routine measurements in a clinical laboratory;
* be able to distinguish different types of immunoassays and immunometric assays, and outline the theoretical principle behind each type;
* be competent in measuring levels of constituents using immunochemical or chromatographic methods;
* be able to evaluate the relative merits of different immunochemical or chromatographic procedures for routine use in clinical biochemistry laboratories;
* be able to describe the biochemical and physiological rationale for laboratory evaluation of endocrine function in health and disease;
* be able to identify the role of a clinical biochemist in the identification and screening for inherited metabolic defects, including an evaluation of the role of molecular biological techniques;
* be able to outline pharmacokinetic principles and their application to the laboratory monitoring of therapeutic drugs; and
* be able to identify and describe the techniques for identification and quantitative analysis of drugs.
Syllabus:
The subject will cover the following topics:
The syllabus will cover the following topics:
Module 1: Immunochemical techniques in clinical biochemistry
* immunoassay principles and procedures, including antibody production (including monoclonal antibodies), optimisation of assay conditions, heterogeneous and homogeneous assay modes, and result calculation;
* immunometric assays and the role of monoclonal antibodies
* signal systems for immunoassays use of radioactive and nonisotopic (enzyme, fluorescent, and chemiluminescent) labels
Module 2: Human genetic disorders
* general principles - single gene defects, genetic components of common diseases, prenatal diagnosis, neonatal screening, diagnosis, heterozygote screening;
* application of molecular biology techniques to genetic defects;
* the range of non-molecular biological techniques employed in diagnosis and screening;
* detailed studies of the phenylketonuria and cystic fibrosis as examples of the role of the clinical biochemistry laboratory
Module 3: Endocrine function
* mechanism of hormone action in relation to diseases;
* control of hormone secretion - the hypothalamus, pituitary, peripheral gland axis in relation to diseases;
* general principles of clinical biochemistry evaluation of endocrine function in health and diseases;
* detailed consideration of:
* thyroid function in relation to diseases;
* adrenocortical hormones in relation to diseases;
* male sex hormones in relation to diseases;
* female sex hormones in relation to diseases and hormones in pregnancy and in parturition.
Module 4: Drug analysis
* pharmacokinetic principles and their application to therapeutic drug monitoring
* toxicology: analysis of drugs and of poisons.
Laboratory Module
* use of immunochemical, chromatographic, chemical and other techniques in analysis of hormones, ions and drugs;
Residential School
This subject contains a compulsory 3 day residential school.
BMS302 Session 1
The information contained in the 2013 CSU Handbook was accurate at the date of publication: 24 April 2013. The University reserves the right to vary the information at any time without notice.