BMS441 Advanced Haematology & Blood Transfusion (16)
CSU Discipline Area: Biomedical Science (BIMSC)
Duration: Two sessions
Abstract:
The Advanced Haematology portion of this subject complements and extends BMS216 Introductory Haematology, by covering selected topics in depth. Topics include: blood cell formation and haemopoietic malignancies, haemoglobinopathies, thalassaemias and disorders of coagulation. The Blood Transfusion component considers the principles of blood group serology and blood transfusion, with a laboratory component focussing on blood group serology.
Assumed previous knowledge for this subject is that the student will be able to describe and recognise cellular components of normal human blood and common blood disorders. It will also be assumed that students can describe haemostasis and have demonstrable skills in haematological techniques in general. Theoretical and practical knowledge of fundamental cytogenetics and immunology will be advantageous.
+ Subject Availability Modes and Locations
| Session 2 | |
|---|---|
| Distance * | Wagga Wagga |
*This subject offering contains a residential school. Please view following information for further details.
Continuing students should consult the SAL for current offering details: BMS441
Where differences exist between the Handbook and the SAL, the SAL should be taken as containing the correct subject offering details.
Enrolment restrictions:
Restricted to postgraduate students only
Objectives:
Upon successful completion of this subject, students should:
* be able to describe in detail the techniques used for the detection and identification of blood group antibodies, the immune haemolytic anaemias and haemolytic disease of the newborn
* be able to demonstrate competency in performing the techniques used for the detection and identification of blood group antibodies, the immune haemolytic anaemias and haemolytic disease of the newborn
* be able to demonstrate a comprehensive understanding of the organisation of a blood bank, product quality control, the selection and testing of donors, blood collection, storage and preservation
* be able to perform laboratory tests applicable to the selection of donor blood for transfusion;
* be able to describe in detail and recognise the role of the laboratory in the diagnosis and treatment of haemopoietic malignancies. This section has a cytogenetics component;
* be able to describe in detail the nature, inheritance, laboratory diagnosis and treatment of the haemoglobinopathies and thalassaemias;
* be able to describe at length the classification, laboratory diagnosis, and treatment of disorders of coagulation and thrombosis;
* be able to demonstrate an understanding of the current and possible future impact of advances in molecular biology/cytogenetics in haematology;
* be able to demonstrate advanced skills in the microscopic examination of the peripheral blood film.
Syllabus:
The subject will cover the following topics:
Module 1: Blood Bank Practice and Procedures This module established the prior knowledge (in basic genetics and immunology) required. It introduces the blood bank; blood and its products; donor selection procedure and safety and quality assurance. Module 2: Erythrocyte blood group systems This module introduces the major (clinically significant) blood groups and mentions the minor blood groups. Module 3: Antibody detection and identification This module focuses on antibody detection and also the indentification of antibodies. Module 4: Clinical conditions associated with immunohaematology This module focuses on case-based findings. Module 5: Blood cell dynamics and haematological malignancy. This module covers blood cell production, control and development, as well as the development, diagnosis and treatment of blood malignancies. Cytogenetic and molecular aspects of haemopoiesis and its disruption are examined in the context of the WHO classification of the leukaemias. Module 6: Haemoglobinopathies, thalassaemias and haemolytic anaemias. This module covers the synthesis and molecular genetics of haemoglobin production and the causes, classification, diagnosis and treatment of haemoglobinopathies and thalassaemias. This module also covers the detailed anatomy and physiology of the red cell and the inherited and acquired defects leading to a reduction in the mean red cell life span as well as the treatment of anaemias by blood transfusion. Module 7: Haemolytic anaemia This module covers the detailed anatomy and physiology of the red cell and the inherited and acquired defects leading to a reduction in the mean red cell life span as the treatment of anaemias by blood transfusion. It builds on the knowledge gained in BMS216 Introductory Haematology which covered enythropoiesis, hypochromic, megaloblastic and some of the haemolytic anaemias, by considering the haemoglobinopathies (i.e. genetic disorders of haemoglobin) and therapy of anaemias by red cell transfusion. Module 8: Disorders of Platelets, Coagulation and Thrombosis This module comprises a study of those diseases in which the impairment of the haemostatic systems is a primary or a secondary feature.
Residential School
This subject contains a compulsory 6 day residential school.
Completion of compulsory laboratory component of this subject.
The information contained in the 2013 CSU Handbook was accurate at the date of publication: 24 April 2013. The University reserves the right to vary the information at any time without notice.