BMS346 Genomics, Proteomics & Bioinformatics (8)
Abstract|
Genomics, proteomics and bioinformatics are three areas that are routinely applied in medical research and throughout the drug-development process. In recent years genomic and proteomic technologies, combined with bioinformatics, and rapid progress in high-throughput technologies, have made it possible to study gene sequences and protein structures and functions. In contrast to studies of single genes or single proteins, genomic and proteomic methods simultaneously investigate large numbers of genes or proteins in one single experiment. This subject will focus on these technologies and will cover the key applications, techniques and recent advances in these fields. This subject contents will include: the human genome, next generation sequencing, expression profiling, proteome families, structural proteomics, gene finding/gene structure, protein function and annotation and application of genomic and proteins databases. In particular techniques such as to mass spectrometry and two dimensional gel electrophoresis, will be covered to study protein-proteins interactions and identification. |
|
|
+ Subject Availability Modes and Location
| Session 2 | | Distance | Wagga Wagga Campus |
Continuing students should consult the SAL for current offering details: BMS346
Where differences exist between the Handbook and the SAL, the SAL should be taken as containing the correct subject offering details.
|
|
Subject information| Duration | Grading System | School: |
|---|
| One session | HD/FL | School of Biomedical Sciences |
|
|
Assumed Knowledge|
BMS240 Human Molecular Genetics or equivalent
|
|
|
Learning OutcomesUpon successful completion of this subject, students should:
- be able to describe, explain and apply the concepts of genomics, proteomics and bioinformatics
- be able to describe genome sequencing and the ways in which genomic data are analysed
- be able to analyse genomic database
- be able to analyse proteomic database
- be able to analyse specific DNA sequences using current bioinformatics tools
- be able to use and apply DNA and protein databanks to search for specific DNA sequences
- be able to interpret DNA array data and critically evaluate the use of this data
- be able to use bioinformatic techniques to analyse DNA and proteins sequences
- be able to discuss how sequence information relates to genes, proteins and cellular strucutures
|
|
|
SyllabusThe subject will cover the following topics:
- Genomics: An introduction to genomic, Databases and sequence comparison technique, genes and genome, principles and applications of DNA microarray technology, transcription profiling, microarray applications, SNP, QTL and genotyping, modern genome sequencing, transcriptomics and microarrays, the concept of transcriptomics, next-gene sequencing
- Proteomics: Introduction to database searching, quantitative proteomics, database resources for genetic variations and disorders, introduction to mass spectrometry, two dimensional gel electrophoresis, post-translational modifications
- Bioinformatics: predicting 3D structures for proteins with unknown experimental (NMR or X-ray) structural data. computerised mapping to hunt for genes, application of online software (NCBI) to analyse, map and blast DNA sequences.
|
|
|
Back
The information contained in the 2016 CSU Handbook was accurate at the date of publication: 06 September 2016. The University reserves the right to vary the information at any time without notice.
