PHM341 Pharmacokinetics (8)

Abstract

This subject is based on an understanding of pharmacology, pharmaceutical chemistry and human physiology, examines pharmaceutical, pharmacokinetic and pharmacodynamic principles pertinent to drug action to attain therapeutic objectives. This subject also looks at typical pharmacokinetics and in special cases such as disease states, pregnancy, lactation, paediatrics and geriatrics, taking into account issues of patient compliance.

+ Subject Availability Modes and Location

Session 1
Internal	Orange Campus
Internal	Wagga Wagga Campus

Continuing students should consult the SAL for current offering details: PHM341
Where differences exist between the Handbook and the SAL, the SAL should be taken as containing the correct subject offering details.

Subject information

Duration	Grading System	School:
One session	HD/FL	School of Biomedical Sciences

Assumed Knowledge

CHM219, PHM231 and the mathematics of exponential/logarithmic functions.

Learning Outcomes

Upon successful completion of this subject, students should:

be able to understand the biological and pharmaceutical factors influencing the absorption, distribution, metabolism and elimination of drugs;
use calculations to demonstrate the importance of pharmacokinetics in determining the bioavailability and disposition of drugs;
demonstrate an appreciation the differences in individuals which influence drug action (pharmacogenetics and pharmacogenomics);
be able to explain the significance of client/patient compliance;
be able to demonstrate an understanding of the mechanisms of drug-drug/drug-food interactions.
be able to outline a number of pharmacokinetic models, including: single compartment, multiple compartment and non-linear pharmacokinetics;

Syllabus

The subject will cover the following topics:

absorption, distribution, metabolism and elimination of drugs;
primary pharmacokinetic parameters including: apparent volume of distribution, clearance, and rate constants associated with drug absorption and elimination;
IV and extravascular administration of drugs;
concepts of bioequivalence and bioavailability;
therapeutic drug monitoring;
multiple dosage regimes;
linear and non-linear pharmacokinetics;
individualised pharmacokinetics e.g. special cases such as disease states, pregnancy, lactation, paediatrics and geriatrics;
principles of drug interactions;

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The information contained in the 2016 CSU Handbook was accurate at the date of publication: 06 September 2016. The University reserves the right to vary the information at any time without notice.