BMS240 Human Molecular Genetics (8)

Abstract

This subject will examine the broad field of genetics. It will cover standard Mendelian genetics, our modern understanding of molecular genetics, and the central dogma (DNA is transcribed to mRNA which is translated to protein). Modern disciplines of applied molecular technology (including proteomics and genomics), the genetic basis of molecular diseases, epigenetics and the genetics of cancer will also be examined.

+ Subject Availability Modes and Location

Session 1
Online	Wagga Wagga Campus
On Campus	Orange Campus
On Campus	Wagga Wagga Campus

Continuing students should consult the SAL for current offering details: BMS240
Where differences exist between the Handbook and the SAL, the SAL should be taken as containing the correct subject offering details.

Subject information

Duration	Grading System	School:
One session	HD/FL	School of Biomedical Sciences

Assumed Knowledge

Students are assumed to have knowledge equivalent to first year undergraduate chemistry and cell biology.

Learning Outcomes

Upon successful completion of this subject, students should:

be able to distinguish between the processes of mitosis and meiosis and their implications in terms of the inheritance of genetic material;
be able to describe Mendelian inheritance patterns
be able to describe and differentiate between different modes of inheritance
be able to describe how genetic information is stored in chromosomes and how chromosomes can be mutated
be able to describe the structure of DNA
be able to describe and apply the flow of genetic information from DNA through to expression as cellular constituents and structure
be able to describe basic DNA mechanisms of replication, translation and transcription
be able to outline how mutations result from alterations in DNA structure
be able to describe standard molecular technologies and the newer technologies of proteomics and genomics
be able to describe the role of epigenetics in human inheritance
be able to describe how genetics plays a role in human disease
be able to describe how mutations play a role in several human genetic diseases (with a focus on cancer)

Syllabus

The subject will cover the following topics:

Chromosomes and cellular reproduction
Basic principles of heredity
Sex determination and sex linked characteristics
Extensions and modifications of basic principles
Pedigree analysis, applications, genetic testing and ethics
Linkage, recombination and eukaryotic gene mapping
Chromosome variation
DNA: The chemical nature of the gene
Chromosome structure and DNA replication
Transcription
RNA molecules and RNA processing
The genetic code and translation
Gene mutations and DNA repair
Molecular genetic analysis and genomics/proteomics
Epigenetics and cancer genetics

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The information contained in the 2017 CSU Handbook was accurate at the date of publication: 25 August 2017. The University reserves the right to vary the information at any time without notice.