Application of basic principles to understand the activity of pharmaceutical agents. Looks at functional group chemistry and implications for physical, chemical and metabolic properties. Major areas include stereochemistry and its relation to drug design and metabolism, and chromatography.
School of Agricultural and Wine Sciences
Only available to Bachelor of Pharmacy students
CHM107 and CHM104
Stereoisomerism and stereoformulae and their pharmaceutical implications;
Conformational analysis in defining receptor structure;
Mechanism of acid-base catalysed ester and amide hydrolysis;
Mechanisms determining pH rate profiles and the relationship to stability of pharmaceuticals;
The role of nucleophiles, electrophiles and metal ions in chemical catalysis;
Factors influencing acid and base conditions;
Comparison of aromatic and aliphatic compounds;
Effect of substituents on acidity/basicity of drugs containing an aromatic nucleus;
Structure-activity effects in local anaesthetics;
Nomenclature and properties of heterocyclic aromatic compounds and their biological role;
Chromatography, TLC, GC, HPLC.
Introduction to radiopharmacy and radioisotope imaging.
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The information contained in the 2018 CSU Handbook was accurate at the date of publication: August 2018. The University reserves the right to vary the information at any time without notice.