CHM219 Organic And Physical Chemistry (8)

Application of basic principles to understand the activity of pharmaceutical agents. Looks at functional group chemistry and implications for physical, chemical and metabolic properties. Major areas include stereochemistry and its relation to drug design and metabolism, and chromatography.

Subject Outlines
Current CSU students can view Subject Outlines for recent sessions. Please note that Subject Outlines and assessment tasks are updated each session.


Session 1 (30)
On Campus
Orange Campus

Continuing students should consult the SAL for current offering details: CHM219. Where differences exist between the Handbook and the SAL, the SAL should be taken as containing the correct subject offering details.

Subject Information

Grading System



One session


School of Agricultural and Wine Sciences

Enrolment Restrictions

Only available to Bachelor of Pharmacy students


CHM107 and CHM104

Learning Outcomes

Upon successful completion of this subject, students should:
  • Be able to demonstrate understanding of the nomenclature and meaning of terms used to describe the stereochemistry of drug molecules;
  • Be able to demonstrate an appreciation of the importance of chemical reactions in determining drug stability and enzymatic catalysis;
  • Have developed abilities in the areas of measurement and recording of data relevant to the understanding of drug structure and reactivity.


This subject will cover the following topics:

Stereoisomerism and stereoformulae and their pharmaceutical implications;
Conformational analysis in defining receptor structure;
Mechanism of acid-base catalysed ester and amide hydrolysis;
Mechanisms determining pH rate profiles and the relationship to stability of pharmaceuticals;
The role of nucleophiles, electrophiles and metal ions in chemical catalysis;
Factors influencing acid and base conditions;
Comparison of aromatic and aliphatic compounds;
Effect of substituents on acidity/basicity of drugs containing an aromatic nucleus;
Structure-activity effects in local anaesthetics;
Nomenclature and properties of heterocyclic aromatic compounds and their biological role;
Chromatography, TLC, GC, HPLC.
Introduction to radiopharmacy and radioisotope imaging.


Current Students

For any enquiries about subject selection or course structure please contact Student Central or or phone on 1800 275 278.

Prospective Students

For further information about Charles Sturt University, or this course offering, please contact info.csu on 1800 275 278 (free call within Australia) or enquire online.

The information contained in the 2018 CSU Handbook was accurate at the date of publication: August 2018. The University reserves the right to vary the information at any time without notice.