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BMS302 Clinical Biochemistry 2 (8)

Abstract

This subject is a continuation of Clinical Biochemistry 1 and covers techniques in measurements of endogenous and exogenous metabolites found in low levels in biological specimens. These metabolites include, but are not limited to, hormones and drugs that are used in therapy and/or that are abused. Techniques inclusive of the various types of immunoassays as well as mass spectrometry are therefore covered. Monogenic diseases are learnt with emphasis on cystic fibrosis and phenylketonuria. Clinical endocrinology is studied and various endocrine disorders are emphasised to illustrate development of endocrine diseases and the importance of clinical biochemistry in diagnosis and management of endocrine disorders. On completion of this subject, a student is equipped with theoretical and technical skills for clinical biochemical investigation of endocrine disorders, monogenic diseases and drugs. Such knowledge is useful for example in further studies in this discipline and also other disciplines such as forensic sciences, dentistry, medicine and veterinary as well as animal sciences, routine and specialist pathology, research and in industry that develops and/or supplies diagnostic technology and consumables.

+ Subject Availability Modes and Location

Session 1
Online*Wagga Wagga Campus
On CampusWagga Wagga Campus
*This subject offering contains a residential school. Please view following information for further details.
Continuing students should consult the SAL for current offering details: BMS302
Where differences exist between the Handbook and the SAL, the SAL should be taken as containing the correct subject offering details.

Subject information

Duration Grading System School:
One sessionHD/FLSchool of Biomedical Sciences

Enrolment restrictions

Prerequisite(s)Incompatible subject(s)
BMS207BMS330

Learning Outcomes

Upon successful completion of this subject, students should:
  • be able to describe and evaluate the various techniques (including but not limited to recognition techniques and mass spectrometry) utilised in measurement of endogenous metabolites and drugs found in low concentrations in biological fluids/tissues in various diseases
  • be able to measure competently the levels of drugs and constituents associated with endocrine and monogenic diseases
  • be able to describe how endocrine diseases and monogenic diseases (e.g. cystic fibrosis and phenylketonuria) arise and to describe and evaluate the patho-biochemical/patho-physiological rationale for screening, diagnosis and management of these diseases
  • be able to describe and analyse the rationale for measuring drugs and describe pharmacokinetic principles and their importance to clinical biochemistry
  • be able to describe and evaluate toxicological exposure involving chemicals and metals
  • be able to work independently and collaboratively in measurement of analyses and to write a scientific report on experimental findings and data interpretation

Syllabus

The subject will cover the following topics:
  • Human monogenic disorders
  • Endocrine diseases
  • Endocrine control of calcium, phosphate and magnesium levels and changes to this control in disease
  • Drugs
  • Techniques (theory and practical) including, but not limited to chemical, immunoassays, chromatographic and mass spectrometry used in investigations and management of endocrine and monogenic diseases and in measurement of ions and drugs

Residential School

This subject contains a compulsory 3 day residential school. Compulsory laboratory work to develop technical skills and interpretation of clinical biochemistry data. Individual, group and class exercises will be carried out, to allow students to learn to work as individuals as well as develop team work skills.

Specialised Resources

Travel to and accommodation is required for distance education students attending the compulsory residential school at a CSU campus. All students are required to have a lab coat, safety glasses and covered footwear for lab based practicals.

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The information contained in the 2018 CSU Handbook was accurate at the date of publication: 20 October 2017. The University reserves the right to vary the information at any time without notice.