RSC441 Advanced Respiratory Laboratory Diagnostics (8)

This subject describes the practical performance and physiological basis of selected specialised clinical respiratory studies. These areas include blood gas analysis, need for domiciliary oxygen and assisted ventilation, assessment of distribution of ventilation and perfusion and bronchial challenge testing. Quality control procedures relevant to the pulmonary function laboratory are also detailed.


Session 2 (60)
Wagga Wagga Campus

Continuing students should consult the SAL for current offering details: RSC441. Where differences exist between the Handbook and the SAL, the SAL should be taken as containing the correct subject offering details.

Subject Information

Grading System



One session


School of Biomedical Sciences

Assumed Knowledge


Learning Outcomes

Upon successful completion of this subject, students should:
  • Be able to discuss the equipment and the testing methods used in determination of blood gas concentrations, homogeneity of pulmonary ventilation and perfusion, bronchial hyperresponsiveness;
  • Be able to describe the calibration procedures and minimum equipment specifications for instruments used in the specialised clinical respiratory tests described above;
  • Be able to discuss the influence of equipment characteristics on the accuracy of physiological measurements attained by these methods;
  • Be able to relate the parameters measured to their physiologic significance, for each of the specialised clinical respiratory tests described above;
  • Be able to describe the process of quality control specific to each of the specialised clinical respiratory tests described above;
  • Be able to discuss the appropriate use of these clinical testing methods as aids in the assessment of respiratory disease;
  • Be able to discuss quality control processes and their application in clinical respiratory laboratories;
  • Be able to apply statistical methods to the monitoring of laboratory quality assurance through longitudinal data collection and analysis


This subject will cover the following topics:
  • Module 1 Blood Gas Analysis
  • Physiological basis of blood gas determination
  • Clinical measurement of blood gas concentrations
  • ABGs
  • Non-invasive blood gas estimation
  • Module 2 Distribution of Ventilation and Perfusion
  • Physiological basis of ventilation and perfusion
  • Clinical measurement of nitrogen washout
  • Equipment and testing specifications
  • Module 3 Challenge tests
  • Physiological basis of challenge testing
  • Challenge protocols
  • Clinical measurement and interpretation of airway hyperresponsiveness
  • Module 4 Laboratory Quality Assurance
  • Quality assurance concepts
  • Statistical methods for quality assurance in the pulmonary function laboratory

Indicative Assessment

The following table summarises the assessment tasks for the online offering of RSC441 in Session 2 2020. Please note this is a guide only. Assessment tasks are regularly updated and can also differ to suit the mode of study (online or on campus).

Item Number
Value %
Quality control project
Review questions
End-of-session examination

The information contained in the CSU Handbook was accurate at the date of publication: May 2021. The University reserves the right to vary the information at any time without notice.