Crystall Swarbrick

Dr Crystall Swarbrick

Research Fellow in Biosecurity Specialising in Infectious Diseases

Gulbali Institute


Dr Swarbrick completed her PhD in structural biology in the Forwood lab at CSU and was awarded a prestigious Khoo Postdoctoral Fellowship to study flaviviral protein-protein and protein-RNA interactions at Duke-NUS in Singapore. During this Fellowship she utilised structural biology, virology and biochemistry, to enhance understanding of the molecular interactions within the viral replication complex towards structure-based drug design. Upon returning to Australia in 2019 Dr Swarbrick worked within the von Itzstein lab assisting a range of projects with a particular focus on inhibitor development. Dr Swarbrick has recently returned to CSU to join the Biosecurity team and her research is currently focused on viral protein interactions with a particular interest in understanding the RNA-protein and protein-protein interactions between the viral proteins and also with host proteins. To this end her research utilises a broad range of structural biology techniques, including X-ray crystallography and cryoelectron microscopy (cryoEM), in conjunction with biochemical and virological assays.

Full publications list on CRO

Recent publications

  • Amyloid fibril formation, structure and domain swapping of acyl-coenzyme A thioesterase-7
    Kumar, M., Teakel, S. L., Swarbrick, C., Chowdhury, I. S., Thorn, D. C., Sunde, M., Carver, J. A. & Forwood, J. K. (ERA2018 Researcher), 2023, In: FEBS Journal. 17 p.
  • Amidoxime prodrugs convert to potent cell-active multimodal inhibitors of the dengue virus protease
    Swarbrick, C., Zogali, V., Chan, K. W. K., Kiousis, D., Gwee, C. P., Wang, S., Lescar, J., Luo, D., von Itzstein, M., Matsoukas, M. T., Panagiotakopoulos, G., Vasudevan, S. G. & Rassias, G., 15 Nov 2021, In: European Journal of Medicinal Chemistry. 224, 11 p., 113695.
  • Subgenomic RNA from Dengue Virus Type 2 Suppresses Replication of Dengue Virus Genomes and Interacts with Virus-Encoded NS3 and NS5 Proteins
    Wang, S., Chan, K. W. K., Naripogu, K. B., Swarbrick, C. M. D., Aaskov, J. & Vasudevan, S. G., 13 Mar 2020, In: ACS Infectious Diseases. 6, 3, p. 436-446 11 p.
  • Cell-active carbazole derivatives as inhibitors of the zika virus protease
    Rassias, G., Zogali, V., Swarbrick, C. M. D., Ki Chan, K. W., Chan, S. A., Gwee, C. P., Wang, S., Kaplanai, E., Canko, A., Kiousis, D., Lescar, J., Luo, D., Matsoukas, M. T. & Vasudevan, S. G., 15 Oct 2019, In: European Journal of Medicinal Chemistry. 180, p. 536-545 10 p.
  • Luteolin escape mutants of dengue virus map to prM and NS2B and reveal viral plasticity during maturation
    Peng, M., Swarbrick, C. M. D., Chan, K. W. K., Luo, D., Zhang, W., Lai, X., Li, G. & Vasudevan, S. G., Jun 2018, In: Antiviral Research. 154, p. 87-96 10 p.
  • NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication
    Swarbrick, C. M. D., Basavannacharya, C., Chan, K. W. K., Chan, S. A., Singh, D., Wei, N., Phoo, W. W., Luo, D., Lescar, J. & Vasudevan, S. G., 15 Dec 2017, In: Nucleic Acids Research. 45, 22, p. 12904-12920 17 p.