I have extensive research expertise with mouse and human models of colon cancer, with a focus on Wnt signalling, a molecular pathway that is critical for stem cell function. I completed my PhD in the Vincan group, studying the function of a Wnt receptor, Frizzled7, in the normal intestinal epithelium, at the initiation of colon cancer and during tumour morphogenesis. I developed novel ex-vivo 3D tumour organoid technologies to dissect the transition from stem cell to cancer stem cell.
In my most recent Postdoc position at QUT in the Hepaticgenomics Research Group, I established a hepatic spheroid model to use in an assay to test potential anti-fibrotic compounds.
Within the Gulbali Institute, my research focus has shifted to Biosecurity and the investigation into anti-virals. I hope to use my expertise in 3D cell cultures to establish methods for interrogating and testing potential anti-viral compounds.